Exact Pseudofermion Action for Monte Carlo Simulation of Domain-Wall Fermion

We present an exact pseudofermion action for hybrid Monte Carlo simulation (HMC) of one-flavor domain-wall fermion (DWF), with the effective 4-dimensional Dirac operator equal to the optimal rational approximation of the overlap-Dirac operator with kernel $H = c H_w (1 + d \gamma_5 H_w)^{-1}$, where $c$ and $d$ are constants. Using this exact pseudofermion action, we perform HMC of one-flavor QCD, and compare its characteristics with the widely used rational hybrid Monte Carlo algorithm (RHMC). Moreover, to demonstrate the practicality of the exact one-flavor algorithm (EOFA), we perform the first dynamical simulation of the (1+1)-flavors QCD with DWF.Comment: 13 pages, 4 figures, v2: Simulation of (1+1)-flavors QCD with DWF, and references added. To appear in Phys. Lett.

City-like Settlement to Industrial City: A Case of Urban Transformation in Huwei Township

[EN] City-like Settlement (German: Teilweise Stadtähnliche Siedlungen) (Schwarz, 1989; Sorre, 1952) plays an important role in the course of civilization, especially the development of industrial cities. Accordingly, this study utilizes Town-Plan Analysis (Conzen, 1960) to deconstruct the relationships between industrialization and settlement formation in order to illustrate the common origin of cities in Taiwan as a result of the emerging economy at the turn of the 20th century. The industrial city of Huwei, known as the “sugar city” with largest yields of cane sugar in Taiwan, had the largest-scale sugar refinery in pre-war East Asia (Williams, 1980). The city has grown and transformed with the factory during the four phases of morphological periods, which began at the establishment of the sugar refinery and worker housing in the middle of the fertile flooding plain in western Taiwan. The spatial arrangement was directed to operational and management efficiency, characterized by the simple grids and hierarchy of layout along the riverside. As the industry enlarged, the new urban core was planned to support the original settlement with shophouses accumulated in the small grids. Followed by postwar modernism (Schinz, 1989), the urban planning again extended the city boundary with larger and polygonal blocks. In the fourth phase, however, the sugar refinery downsized, leading to the conversion of the worker housing and the merging of the factory and the city that slowly brought to its present shape. The morphological process results in the concentric structure from the sugar refinery, providing valuable references for the preservation of the sugar industry townscape, and unveils the influence of industrialization as well as the special urban development pattern in Taiwan.Chen, C.; Chen, C. (2018). City-like Settlement to Industrial City: A Case of Urban Transformation in Huwei Township. En 24th ISUF International Conference. Book of Papers. Editorial Universitat Politècnica de València. 833-841. https://doi.org/10.4995/ISUF2017.2017.5923OCS83384

Exhaled breath condensate based breath analyser

Exhaled breath condensate (EBC) based breath analysis has gained significant interest in pulmonary disease diagnostics over the past few years due to the non-invasiveness and simplicity of the technique. Most approaches to date have separated EBC collection from the subsequent lab-based analysis, more notably, integrated EBC collector and analyser do not exist. Under current suggested protocol EBC samples for hydrogen peroxide analysis needs freezing at -70 C immediately after collection but still exhibit instabilities in concentration. To address those difficulties and to provide easy-to-use devices for patients, we have proposed a portable integrated EBC analyser, which gives measurement results within 3 minutes. The device incorporates Peltier cooling for sample collection; electronics control system and a disposable chemically modified amperometric sensor. Cooling system and device architecture were designed based on thermofluidic analysis of Falkner-Skan solution. Theoretical modelling and experimental evidence suggest that previously reported large variations between analyte concentrations arise from poor control of the condensation process. Fundamental studies suggest higher condensation temperature favours more concentrated analyte collection, relieving the burden on electrochemical sensor limit of detection (LOD). Low hydrogen peroxide in EBC presents another challenge. We have developed a modified Prussian blue (PB) sensor, by blending PB in conducting polymer matrix to increase PB density on electrode as well as cross linking matrix to improve the mechanical properties and enhance processability. Full mechanistic investigation using rotation disk electrode and chronoamperometry experiments reveal the kinetics of the sensor and informed subsequent development. The sensor has been demonstrated to measure hydrogen peroxide in EBC.Open Acces

From Isovist to Spatial Perception: Wayfinding in Historic Quarter

Based on the assumption that human behaviours are mainly affected by physical and animate environments, this empirical research takes the changeful and complex historical district in Tainan to observe wayfinding behaviours. An a priori analysis of the isovist fields is conducted to identify spatial characteristics. Three measures, the relative area, convexity, and circularity, are applied to scrutinize the possible stopping points, change of speed, and route choices. Accordingly, an experiment is carried out to observe spatial behaviours and different influences of social stimuli. Results show that social interactions afford groups and pairs to perform better than individual observers in wayfinding.© 2016. The Authors. Published for AMER ABRA by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creative commons.org/licenses/by-nc-nd/4.0/).Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.Keywords: wayfinding; isovist; spatial perception and social stimuli; historic quarte

Therapeutic and Radiosensitizing Effects of Armillaridin on Human Esophageal Cancer Cells

Background. Armillaridin (AM) is isolated from Armillaria mellea. We examined the anticancer activity and radiosensitizing effect on human esophageal cancer cells. Methods. Human squamous cell carcinoma (CE81T/VGH and TE-2) and adenocarcinoma (BE-3 and SKGT-4) cell lines were cultured. The MTT assay was used for cell viability. The cell cycle was analyzed using propidium iodide staining. Mitochondrial transmembrane potential was measured by DiOC6(3) staining. The colony formation assay was performed for estimation of the radiation surviving fraction. Human CE81T/VGH xenografts were established for evaluation of therapeutic activity in vivo. Results. AM inhibited the viability of four human esophageal cancer cell lines with an estimated concentration of 50% inhibition (IC50) which was 3.4–6.9 μM. AM induced a hypoploid cell population and morphological alterations typical of apoptosis in cells. This apoptosis induction was accompanied by a reduction of mitochondrial transmembrane potential. AM accumulated cell cycle at G2/M phase and enhanced the radiosensitivity in CE81T/VGH cells. In vivo, AM inhibited the growth of CE81T/VGH xenografts without significant impact on body weight and white blood cell counts. Conclusion. Armillaridin could inhibit growth and enhance radiosensitivity of human esophageal cancer cells. There might be potential to integrate AM with radiotherapy for esophageal cancer treatment